TRPML – Recent advances in the use of MAPK13 inhibitors for prostate cancel therapy

Low levels of insoluble truncated tau were observed only in the sarkosyl-insoluble fraction of Tg-FDD-Tau mice brains, which may reflect the higher number of cells that were detected using Ab Tau-C3 by immunohistochemistry in Tg-FDD-Tau mice compared to Tg-Tau mice

By cahrr May 26, 2023TRPML

Low levels of insoluble truncated tau were observed only in the sarkosyl-insoluble fraction of Tg-FDD-Tau mice brains, which may reflect the higher number of cells that were detected using Ab…

C99 was purified via IMAC, during which SDS and urea were removed and replaced with 0

By cahrr November 16, 2022TRPML

C99 was purified via IMAC, during which SDS and urea were removed and replaced with 0.05% LMPG, a lyso-phospholipid detergent. sulindac sulfide, flurbiprofen, and ibuprofen, were shown to reduce the…

Model-based predictions of the serum biokinetics during therapy were compared to actual measurements

By cahrr September 3, 2022TRPML

Model-based predictions of the serum biokinetics during therapy were compared to actual measurements. Results Variability of the RM time-integrated activity coefficients ((37.37.5) h) indicates the need for patient-specific dosimetry. and…

We describe the case of severe exacerbation of interstitial lung disease in a 76-year-old female with esophageal sclerosis who was treated with oral nifedipine for Raynaud syndrome

By cahrr November 18, 2021TRPML

We describe the case of severe exacerbation of interstitial lung disease in a 76-year-old female with esophageal sclerosis who was treated with oral nifedipine for Raynaud syndrome. strong class="kwd-title" Key…

Histogram depicts the quantitative difference in the -galactosidase activity in AKAP4 shRNA3 transfected COLO 205 and HCT 116 cells when compared with NC shRNA transfected cells

By cahrr August 5, 2021TRPML

Histogram depicts the quantitative difference in the -galactosidase activity in AKAP4 shRNA3 transfected COLO 205 and HCT 116 cells when compared with NC shRNA transfected cells. part of AKAP4 in…

All authors read and approved the final manuscript

By cahrr August 1, 2021TRPML

All authors read and approved the final manuscript. Notes Ethics approval and consent to participate Investigation has been conducted in accordance with the ethical standards and according to the Declaration…